Trois disques d'Europe orientale (Roumanie, Transylvanie)

Synaptic Ménage à Trois

Regulation of neurotransmitter receptor localization is critical for synaptic function and plasticity. In this issue of Neuron, Matsuda and colleagues (Matsuda et al., 2016) uncover a transsynaptic complex consisting of neurexin-3, C1q-like proteins, and kainate receptors that drives glutamate receptor clustering at hippocampal synapses.

Ménage à trois

Ménage à trois

Glioblastoma is an aggressive primary brain cancer. Given our interest in novel immunotherapies, we have recently shown that inhibiting CTLA-4, PD-L1 and IDO results in a dramatic survival advantage in mice with brain tumors. Our preclinical study supports the rapid translation of this approach into phase I clinical trial.

The Maturely, Immature Orientale Impact Basin

Introduction: The Moon is consistently bombarded by large and small projectiles that weather its surface. This includes micrometeorites, cosmic and solar rays, and solar wind implantation and sputtering in a process known as space weathering. Based on data from the Clementine spacecraft, several studies [2, 4, 5] have shown that the degree of this process imparted upon the lunar surface can be ...

Formation of the Orientale lunar multiring basin.

Multiring basins, large impact craters characterized by multiple concentric topographic rings, dominate the stratigraphy, tectonics, and crustal structure of the Moon. Using a hydrocode, we simulated the formation of the Orientale multiring basin, producing a subsurface structure consistent with high-resolution gravity data from the Gravity Recovery and Interior Laboratory (GRAIL) spacecraft. T...